Hi Eun. I have pku, along with my three sisters.When inheriting a genetic disorder, the chances of ping it to an offspring is 1 out of 4, so a 25% chance. So the right answer is 1. But just a side note: in my family i have two sisters and a brother. (1 out of 4) 3 out of 4 have pku, so that "1 out of 4 chances" is an educated estimate of how many children will have it. but it differs for everyone.
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